In 1999, the group underwent a name change, however, it continued on to release two albums under the name IMx such as Introducing IMx (1999) and IMx (2001).
The group also branched out into acting and appeared such shows as A Different World, Sister, Sister.
Houston made guest appearances on fellow TUG Entertainment artist Mila J's single "Good Lookin' Out" and Yung Joc's single "1st Time"; he made appearances in both music videos.
Houston featured on 50 Cent's remix to the hit single "Candy Shop", which also featured wss the group Dame Four.
Marques played the role for five of the show's six seasons.
The show wrote his character out of the script during the fifth season, but he made a guest appearance in the series finale.
In 1997, he had a brief cameo in the movie "Good Burger", a spin-off from a sketch on the Nickelodeon show "All That" starring Kenan Thompson and Kel Mitchell. Houston and his IMx (formerly Immature) band members made an appearance in Destiny's Child music video for the single "No, No, No Part 1" off their 1998 album The Writing's on the Wall.
In 1999, shortly after Houston's run on the Sister, Sister show ended, Marques had a brief cameo in Destiny's Child's video rendition of The Writing's on the Wall single Jumpin', Jumpin' directed by Joseph Kahn.
He then starred in the sequel, Somebody Help Me 2 in 2010.Houston made guest appearances on Jones' album Food for Thought (2004) on songs titled "Sexapade" and "What Cha Doin' Tonight", while Jones made a guest appearance on Houston's album Naked on the song titled "All Because of You".The two also collaborated on "For Your Love", a song from an unreleased album by Young Rome.Houston announced on 106 & Park that IMx planned to record another group album together for 2011.In October 2012, Marques Houston announced a new studio album, Famous slated for release August 27, and released "Speechless" as a promotional preview via free digital download.